The 82nd Division was re designated February 13, 1942 as Division Headquarters, 82nd Division. After the outbreak of World War II, it was recalled to active service on March 25, 1942, and reorganized at Camp Claiborne, Louisiana, under the command of Major General Omar N. Bradley. During this time spent in training, the division brought together three officers who would ultimately steer the US Army during the next two decades: Matthew B. Ridgway, James M. Gavin, and Maxwell D. Taylor.

On August 15, 1942, the 82nd Infantry Division became the first airborne division in the U.S. Army, and was redesignated the 82nd Airborne Division. In April 1943, paratroopers of the 82nd Airborne Division deployed to North Africa under the command of Major General Matthew B. Ridgway to participate in the campaign to invade Italy. The Division's first two combat operations were parachute assaults into Sicily on July 9 and Salerno on September 13, 1943. The initial assault on Sicily, by the 505th Parachute Infantry Regiment, was the first regimental sized combat parachute assault conducted by the United States Army. The first glider assault did not occur until Operation Neptune as part of the D-Day (Invasion of Normandy, June 6, 1944) Glider troopers of the 319th Glider Field Artillery, the 320th Glider Field Artillery and the 325th Glider Infantry did participate in the Italian campaign but came in by landing craft at Maiori (319th) and Salerno (320th, 325th).